Like all pay-to-win games, it is easy to learn and can be entertaining, but unless you sink tons of money into it you cant ever win.
In-game events are designed to ensure the AI wins unless you have the EXACT combination of fully leveled Uncommon or Rare characters in your roaster. New characters are impossible to win, but throw enough money into the Random Character Cover lottery and you will have one fully leveled by the end of the event. The AI will always get all the points it needs to get off its most powerful abilities within two or three rounds while you struggle to fill a power that only requires five points.
You can choose which of you opponents characters you want to attack first, but the order in which your team takes damage is based on what color tiles you match; and if you have two characters who utilize the same color for a power, the weaker of the two will always be put in front to receive damage when that color is matched.
Character cards, abilities belonging to another character you have faced and defeated that can only be used once, ensure you never have an unfair advantage over your opponent and can lead to situations where your best characters are defeated by starter characters. Several older, cheaper characters are poorly balanced, able to do thousands of points of damage for very few action points. Additional character slot tokens and other in-game currency can be won but the game releases so many new characters (they have released at least 10 so far this year) and so many events depend on you having them in order to play that you feel forced to pay real money to continue playing.
There is only one recurring events that does not require you to have certain characters to play, and that is the PvP section which has its own problems. Your opponent is chosen at random and while you can choose to skip up to four for free, eventually you have to either fight someone more powerful than you or pay in-game currency to skip.
If you are looking for a casual matching game, look somewhere else. If you are looking for a competitive investment of both time and money, there are better choices but this one is based on the Marvel comics, so it appeals to some.
Alorxico about MARVEL Puzzle Quest: Hero RPG, vR100.0.342